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Product Name | EP4 Antagonist 14 |
Description | An EP4 antagonist (IC50 = 1.1 nM in a reporter assay); inhibits PGE2-induced β-arrestin recruitment in the same cells (IC50 = 0.9 nM); decreases PGE2-induced expression of mRNA encoding Il4, Mrc1, Chil3, Cxcl1, Trem2, and Arg1 in RAW 264.7 macrophages at 10 µM; inhibits tumor growth and increases infiltration of CD8+ T cells into tumors in combination with an anti-PD-1 antibody in a CT26 murine colon cancer model at 30 mg/kg per day |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | PGE2 Receptor 4 Antagonist 14|Prostaglandin E2 Receptor 4 Antagonist 14 |
Gene, Accession, CAS # | n/a |
Catalog # | 38427-10 |
Price | $531.00 |
Order / More Info | EP4 Antagonist 14 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |