Ro 5126766 from CAYMAN CHEMICAL COMPANY
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| Product Name | Ro 5126766 |
| Description | A dual inhibitor of MEK1 (IC50 = 160 nM) and Raf kinases (IC50s = 56, 19, and 8.2 nM for C-RAF, B-RAF, and B-RAFV600E, respectively); selective for these kinases over a panel of 254 additional kinases at 10 µM; decreases MEK and ERK phosphorylation in a panel of seven cancer cell lines expressing mutant K-RasG13D, K-RasQ61K, K-RasG12D, H-RasG12D, or B-RAFV600E at 1 µM; inhibits proliferation of SK-MEL-28, SK-MEL-2, MIA PaCa-2, SW480, and HCT116 cancer cells (IC50s = 28-227 nM) but not A549, HCT15, or PC3 cancer cells (IC50s = >1,000 nM for all); reduces tumor growth in an HCT116 mouse xenograft model at 25 mg/kg four times per day |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Avutometinib|CH5126766|VS-6766 |
| Gene, Accession, CAS # | CAS: 946128-88-7 |
| Catalog # | 29197-1 |
| Price | $74 |
| Order / More Info | Ro 5126766 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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