EPZ5676 from CAYMAN CHEMICAL COMPANY
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| Product Name | EPZ5676 |
| Description | A highly potent and selective inhibitor of DOT1L histone methyltransferase activity (Ki = 80 pM); inhibits the H3K79 methylation in various human leukemia cell lines (IC50s = 3-5 nM), decreasing MLL-fusion target gene expression and inhibiting proliferation; intravenous infusion of EPZ-5676 at a dose of 35 mg/kg can regress tumors in a rat xenograft model of MLL-rearranged leukemia |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1380288-88-9 inhibitors DOT1L histones methyltransferases MLL-rearranged leukemias epigenetics inhibits inhibitions EPZ5676 EPZ 5676 DOT1L domains genes DNA damages repairs cells cycles regulations MLL drugs aminonucleosides expressions translocations intravenous infusions tumors regression rats xenografts EPZ-5676 potent selective H3K79 |
| Gene, Accession, CAS # | CAS: 1380288-87-8 |
| Catalog # | 16175-25 |
| Price | $479.00 |
| Order / More Info | EPZ5676 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY