Roflumilast N-oxide from CAYMAN CHEMICAL COMPANY
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| Product Name | Roflumilast N-oxide |
| Description | A PDE4 inhibitor (IC50 = 2 nM) and active metabolite of roflumilast; selective for PDE4 over PDE1-3 and PDE5 (IC50s = >10,000 nM for all); It reduces TNF-α-induced ICAM-1 and eotaxin levels when used in combination with PGE2 in GM06114 human fetal lung fibroblasts (IC50s = 0.9 and 0.5 nM, respectively); reverses cigarette smoke extract-induced reductions in ciliary beat frequency in isolated human bronchial epithelial cells at 2 nM; also increases plasma GLP-1 levels in a glucose challenge in diabetic db/db mice at 10 mg/kg, as well as prevents increases in blood glucose in db/db mice at 3 mg/kg per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | PDE 1 2 3 4 5 ICAM1 IL1β RNO |
| Gene, Accession, CAS # | CAS: 292135-78-5 |
| Catalog # | 33975-5 |
| Price | $63 |
| Order / More Info | Roflumilast N-oxide from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY