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Product Name | MS1943 |
Description | A PROTAC that drives EZH2 degradation; inhibits EZH2 (IC50 = 120 nM) and is selective for EZH2 over EZH1, as well as a panel of 45 kinases at 10 µM; induces EZH2 degradation and reduces H3K27me3, as well as induces activation of the unfolded protein response pathway in MDA-MB-468 TNBC cells at 4 µM; inhibits the growth of MDA-MB-468 cells in vitro (GI50 = 2.2 µM); reduces tumor volume in an MDA-MB-468 mouse xenograft model at 50 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | MS-1943 EZH MDAMB468 MDAMB |
Gene, Accession, CAS # | CAS: 2225938-17-8 |
Catalog # | 35466-5 |
Price | $400.00 |
Order / More Info | MS1943 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |