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Product Name | ML-382 |
Description | An MRGPRX1 positive allosteric modulator; potentiates BAM 22P (8-22)-induced activation of MRGPRX1 in HEK293 cells expressing the human receptor (EC50 = 0.19 µM) but does not potentiate PAMP-induced activation of MRGPRX2 in HEK293 cells expressing the human receptor at 5 µM; selective for MRGPRX1 over a panel of 68 GPCRs, ion channels, and transporters at 10 µM; enhances BAM 22P (8-22)-induced inhibition of high-voltage-activated ICa in dorsal root ganglion neurons isolated from transgenic mice expressing human MRGPRX1 at 5 µM; intrathecal administration decreases formalin-induced paw licking and shaking in MRGPRX1 transgenic mice at 25 µM/animal |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | VU0485891 |
Gene, Accession, CAS # | CAS: 1646499-97-9 |
Catalog # | 36668-50 |
Price | $500.00 |
Order / More Info | ML-382 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |