WZ3146 from CAYMAN CHEMICAL COMPANY
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| Product Name | WZ3146 |
| Description | An inhibitor of mutant EGFRs (IC50s = 2-2,740 nM); selective for EGFR mutants including EGFRL858R and EGFRDel E746_A750 (IC50s = 2 nM for both) over wild-type EGFR (IC50 = 750 nM); inhibits ERBB2Ins G776V,C and wild-type ERBB2 (IC50s = 10 and 24 nM, respectively, in Ba/F3 cells) but not the ERBB2 gatekeeper mutant; decreases phosphorylation of EGFR, AKT, and ERK1/2 in H1975 NSCLC cells at 10-1,000 nM; inhibits proliferation of PC-9 and PC-9 GR cells (EC50s = 15 and 3 nM, respectively) |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | WZ-3146 HN-11 ERBB-2 T7981 ERK-1 2 H-1975 PC9 PC9GR WT F-3 EGFR-Del E746_A750 ERBB2-Ins G776V,C ERK-1/2 nonsmall HER2 HER |
| Gene, Accession, CAS # | CAS: 1214265-56-1 |
| Catalog # | 23440-10 |
| Price | $341.00 |
| Order / More Info | WZ3146 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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