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Product Name | NBI 74330 |
Description | A CXCR3 antagonist (Ki = 3.6 nM in a radioligand binding assay); inhibits CXCL10- or CXCL11-induced calcium mobilization in RBL cells expressing human CXCR3 (IC50 = 7 nM for both); inhibits CXCL11-induced chemotaxis of CXCR3-expressing H9 cells and PHA/IL-2 T cells (IC50s = 3.9 and 6.6 nM, respectively); reduces peritoneal lymphocyte migration in a mouse model of peritonitis at 100 mg/kg; reduces the size and number of aortic arch atherosclerotic lesions in Ldlr-/- mice; reduces spinal cord microglial activation and levels of CXCL4, CXCL9, and CXCL10 and decreases thermal and mechanical hyperalgesia in a rat model of chronic constriction injury-induced neuropathic pain |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | CXCR-3 CXC CXCL-11 H-9 IL2 radio ligand athero sclerotic hyper algesia neuro pathic |
Gene, Accession, CAS # | CAS: 855527-92-3 |
Catalog # | 28442-1 |
Price | $359.00 |
Order / More Info | NBI 74330 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |