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Product Name | Kirenol |
Description | A diterpenoid with diverse biological activities; inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays (MICs = 39-156 and 312.5-625 µg/ml, respectively); reduces K652 cell viability (IC50 = 18.19 µg/ml); reduces motor deficit, delays disease onset, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th7 cells in a mouse model of EAE at 2 mg/kg; reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression in a rat model of collagen-induced arthritis from 1-4 mg/kg; topical administration reduces edema induced carrageenan, CFA, and formalin in rats at 0.3-0.5% w/w |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | K-652 CD4 IL17A NFkB antiarthritic antiinflammatory GR-α IFNγ CD-4 Th-1 7 Sigesbeckia Siegesbeckia |
Gene, Accession, CAS # | CAS: 52659-56-0 |
Catalog # | 26212-5 |
Price | $62.00 |
Order / More Info | Kirenol from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |