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Product Name | AS-605240 |
Description | A potent inhibitor of PI3Kγ; inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner (IC50s = 8, 60, 270, and 300 nM, respectively); inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells (IC50 = 90 nM); suppresses joint inflammation in mouse models of rheumatoid arthritis; reduces RANTES-induced peritoneal neutrophil recruitment in a mouse model of leukocyte chemotaxis (ED50 = 9.1 mg/kg) |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | phosphoinositide 3-kinases PI3-kinase PI3-K PI3K phosphoinositide phosphatidylinositols inibitors inflammation arthritis rheumatoid peritonitis neutrophils recruitment as605240 |
Gene, Accession, CAS # | CAS: 648450-29-7 |
Catalog # | 10007707-25 |
Price | $190.00 |
Order / More Info | AS-605240 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |