TAS 115 (methanesulfonate) from CAYMAN CHEMICAL COMPANY
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| Product Name | TAS 115 (methanesulfonate) |
| Description | A multi-kinase inhibitor; an inhibitor of PDGFRα and PDGFRβ (IC50s = 0.81 and 7.06 nM, respectively), c-FMS (IC50 = 15 nM), VEGFR2 and VEGFR1 (IC50s = 30 and 140 nM, respectively), Met (IC50 = 32 nM), and FGFR2 (IC50 = 340 nM); inhibits Axl, c-Kit, Src, and FLT1; inhibits VEGF-induced VEGFR2 phosphorylation in HUVECs and Met phosphorylation in Met-amplified MKN45 cells; inhibits VEGF-dependent growth of HUVECs (IC50 = 0.019 µM); inhibits growth of Met-amplified MKN45 cells (GI50 = 0.032 µM); reduces tumor growth in a MKN45 mouse xenograft model (ED50 = 8 mg/kg) |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1190836-34-0 TAS115 multikinase PDGFR cFMS VEGFR FGFR cKit FLT MKN MCF7 CSF1R |
| Gene, Accession, CAS # | CAS: 1688673-09-7 |
| Catalog # | 33593-1 |
| Price | $49.00 |
| Order / More Info | TAS 115 (methanesulfonate) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY