Ponesimod from CAYMAN CHEMICAL COMPANY
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| Product Name | Ponesimod |
| Description | A potent S1P1 receptor agonist (IC50s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P1-S1P5, respectively, in a radioligand binding assay); selectively activates S1P1 in a GTPγS assay (EC50s = 5.7, >10,000, 105, 1,108, 59.1 nM, for S1P1-S1P5, respectively); reduces the number of circulating lymphocytes in rats in a dose-dependent manner; reduces edema, protein extravasation, neutrophil activity, and skin levels of the proinflammatory cytokines IL-1β, IL-6, IFN-γ, and TNF-α in a mouse model of delayed-type hypersensitivity; prevents footpad swelling in a rat model of adjuvant-induced arthritis , |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1352632-69-9 ACT128800 IL1β IL1b IL6 TNFα TNFa ACT 128800 EDG1 S1P-1 2 3 4 5 S1P2 S1P3 S1P4 S1P5 GTP-γS IFNγ interferon interleukin |
| Gene, Accession, CAS # | CAS: 854107-55-4 |
| Catalog # | 22053-25 |
| Price | $586 |
| Order / More Info | Ponesimod from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY