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Product Name | MK-2461 |
Description | A c-MET inhibitor (IC50s = 0.4-2 nM for wild-type and mutant forms); selective for c-MET over a panel of 13 additional kinases (IC50s = 22-7,800 nM) but does inhibit Ron and FLT1 (IC50s = 7 and 10 nM, respectively); inhibits autophosphorylation of FGFR2 and PDGFRα in KATO III cells at 2 µM; reduces proliferation in a panel of cancer cell lines, including cells expressing constitutively active c-MET, FGFR2, or PDGFR (IC50s = ≤ 1 µM for all); reduces tumor growth in a GTL-16 gastric cancer mouse xenograft model (10-200 mg/kg) |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 1196681-15-8 MK2461 cMET FLT 1 FGFR 2 A 549 GTL16 |
Gene, Accession, CAS # | CAS: 917879-39-1 |
Catalog # | 32964-10 |
Price | $544.00 |
Order / More Info | MK-2461 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |