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Product Name | BFH772 |
Description | An inhibitor of VEGFR2 (IC50 = 0.0027 µM for the human receptor); selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 µM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2; inhibits VEGF-induced proliferation of HUVECs (IC50 = <0.01 nM); inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice at 1 and 3 mg/kg per day; inhibits primary tumor and metastasis growth in a B16 melanoma mouse model at 3 mg/kg per day |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | BFH-772 VEGFR-1 2 3 BRAF Tie-2 B-16 |
Gene, Accession, CAS # | CAS: 890128-81-1 |
Catalog # | 21386-1 |
Price | $38.00 |
Order / More Info | BFH772 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |