4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from CAYMAN CHEMICAL COMPANY
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| Product Name | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone |
| Description | A tobacco-specific nitrosamine carcinogen; metabolites induce DNA alkylation and methylation; increases the protein levels of DNMT1 in mouse bronchial epithelial cells within one day and increases hypermethylation of the tumor suppressor genes Chd13, Prdm2, and Runx3 in lung tissue at a single dose of 100 mg/kg; NNK induces adenomas and adenocarcinomas, which are present after 16 and 50 weeks, respectively, in mouse lung following a single dose of 10 µmol/animal; lifetime administration results in a 90% lung tumor incidence in rats at 63.5 mg/animal |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NNK |
| Gene, Accession, CAS # | CAS: 64091-91-4 |
| Catalog # | 16414-5 |
| Price | $86.00 |
| Order / More Info | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY