GI 254023X from CAYMAN CHEMICAL COMPANY
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| Product Name | GI 254023X |
| Description | An ADAM10 inhibitor (IC50 = 5.3 nM); selective for ADAM10 over ADAM17, MMP-1 and MMP-3 (IC50s = 541, 108, and 187 nM, respectively); inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively); inhibits constitutive, but not PMA-induced shedding of CX3CL1 in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 µM, respectively); inhibits constitutive, but not PMA-induced, secretion of IL-6R from THP-1 macrophages (IC50s = 1.8 and >10 µM, respectively); decreases Aβ42-induced shedding of LRP1 in HBMECs; increases Aβ42 transit across an in vitro blood brain barrier model; reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer's disease at 200 mg/kg |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | GI 4023|SRI 028594 |
| Gene, Accession, CAS # | CAS: 260264-93-5 |
| Catalog # | 28284-5 |
| Price | $166.00 |
| Order / More Info | GI 254023X from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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