NNC-711 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | NNC-711 (hydrochloride) |
| Description | A GAT-1 inhibitor (IC50 = 0.04 µM for the human transporter); selective for GAT-1 over human GAT-3 and BGT-3 (IC50s = 1,700 and 622 µM, respectively), rat GAT-2 (IC50 = 171 µM), and a panel of 21 receptors and ion channels (IC50s = >50 µM for all) in radioligand binding assays; inhibits GABA uptake in rat synaptosome preparations, neurons, and glia (IC50s = 47, 1,238, and 636 nM, respectively); inhibits PTZ- or DMCM-induced clonic seizures in mice (ED50s = 1.2 and 3 mg/kg, respectively), as well as audiogenic tonic seizures in mice (ED50 = 0.23 mg/kg) and PTZ-induced tonic seizures in rats (ED50 = 1.7 mg/kg); intrathecal administration decreases mechanical allodynia and thermal hyperalgesia in a rat model of CCI-induced neuropathic pain at 100 or 200 µg/animal |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NNC 05-711|NO-711 |
| Gene, Accession, CAS # | CAS: 145645-62-1 |
| Catalog # | 29687-5 |
| Price | $139.00 |
| Order / More Info | NNC-711 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY