PYR41 from CAYMAN CHEMICAL COMPANY
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| Product Name | PYR41 |
| Description | An irreversible inhibitor of ubiquitin-activating enzyme (E1; IC50 = 50 = 6.4 µM); selective for E1 over E2 but does inhibit autoubiquitination of the HECT domain E3 Nedd4 at 50 µM; inhibits proteasome-dependent and -independent ubiquitination and protein degradation at 50 µM; preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells at 1-20 µM; also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | PYR-41 E-1 2 3 auto-ubiquitination NFκB TRAF-6 p-53 JAK-2 Bcrabl Tumor necrosis factor janus kinase 2 |
| Gene, Accession, CAS # | CAS: 418805-02-4 |
| Catalog # | 15226-5 |
| Price | $51 |
| Order / More Info | PYR41 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY