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Product Name | CADD522 |
Description | An inhibitor of RUNX2-DNA binding; inhibits RUNX2 binding to OSE2 oligonucleotides in a cell-free assay, as well as inhibits RUNX2 enrichment on MMP-13 promoters in MCF-7 cells from 100-1,000 nM; decreases clonogenic survival in a panel of nine breast cancer cell lines at 50 µM; decreases the expression of MMP-13 and VEGF in ectopic RUNX2-expressing T47D-RUNX2 and MCF-7-RUNX2 cells; reduces tumor volume and incidence in the MMTV-PyMT transgenic mouse model of breast cancer at 20 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | CADD-522 RUN OSE MMP13 MCF7 MMP13 T47DRUNX2 MMTVPyMT MCF7RUNX2 |
Gene, Accession, CAS # | CAS: 199735-88-1 |
Catalog # | 36679-5 |
Price | $44.00 |
Order / More Info | CADD522 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |