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Product Name | CPI-1189 |
Description | A benzamide; inhibits phosphorylation of p38 MAPK in IL-1β-stimulated primary rat astrocytes by 70 to 80% at 10-300 nM; decreases TNF-α-induced apoptosis in the corpus callosum and septum, but not in the neocortex or basal ganglia, as well as reduces TNF-α-induced decreases in GFAP levels in isolated rat brain slices at 20 mg/kg per day; decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, induced by TNF-α in a rat model of AIDS dementia at 20 mg/kg per day; reduces crypt loss and decreases the number of ulcers and inflammatory cells in colonic lesions in mouse models of colitis induced by TNBS or DSS at 30 mg/kg per day |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 210475-67-5 CPI-1189 antiinflammatory neuro-protective IL1β TNFα |
Gene, Accession, CAS # | CAS: 183619-38-7 |
Catalog # | 29187-25 |
Price | $32.00 |
Order / More Info | CPI-1189 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |