LX2343 from CAYMAN CHEMICAL COMPANY
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| Product Name | LX2343 |
| Description | An inhibitor of BACE1 and PI3K (IC50s = 11.43 and 15.99 µM, respectively); inhibits STZ-induced accumulation of Aβ40 and Aβ42 in both HEK293-APPSW and CHO-APP cells in a concentration-dependent manner; inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as sAPPβ protein levels; reduces levels of Aβ40 and Aβ42, as well as thioflavine S staining, in cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer's disease at 10 mg/kg/day; reduces cortical levels of p62 protein and PI3K, Akt, and mTOR phosphorylation; decreases path length and escape latency time in the Morris water maze in APP/PS1 mice at 10 mg/kg/day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | LX 2343 BACE 1 BAC E1 PI 3K 42 HEK 293 HEK293APP HEK293APPSW APP SW CHOAPP Thr668 Thr 668 β APPPS1 PS m TOR p 62 |
| Gene, Accession, CAS # | CAS: 333745-53-2 |
| Catalog # | 27799-5 |
| Price | $168.00 |
| Order / More Info | LX2343 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY