CC-115 from CAYMAN CHEMICAL COMPANY
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| Product Name | CC-115 |
| Description | A dual inhibitor of mTOR and DNA-PK (IC50s = 0.021 and 0.013 µM, respectively); selective for mTOR and DNA-PK over PI3Kα, ATM, and ATR (IC50s = 0.85, >30, and >30 µM, respectively); inhibits growth in a panel of 123 cancer cell lines, including breast, head and neck, and lung cancer cells (GI50s = 0.015-1.77 µM); inhibits NHEJ in CAL-51, MDA-MB-231, PC3, and HCT116 cells (IC50s = 3.15, 2.16, 2.72, and 6.35 µM, respectively); reduces tumor growth in a PC3 prostate cancer mouse xenograft model at 0.25, 0.5, and 1 mg/kg twice per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | CC115 DNAPK nonhomologous CAL51 MDAMB231 MDAMB-231 MDA-MB231 PC-3 HCT-116 |
| Gene, Accession, CAS # | CAS: 1228013-15-7 |
| Catalog # | 19420-5 |
| Price | $139.00 |
| Order / More Info | CC-115 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY