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Product Name | NSC 109555 |
Description | An inhibitor of Chk2 (IC50 = 200 nM in a cell-free kinase assay); selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK (IC50s = 210, 6,000, 7,400, and 7,100 nM, respectively); inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC50 = 240 nM); inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro; potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of ROS in MIA PaCa-2 cells at 1,250 nM |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | DDUG|NCI C04808 |
Gene, Accession, CAS # | CAS: 15427-93-7 |
Catalog # | 19811-5 |
Price | $84.00 |
Order / More Info | NSC 109555 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |