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Product Name | Nitecapone |
Description | An S-COMT inhibitor (IC50 = 300 nM in rat liver); is selective for S-COMT over tyrosine hydroxylase, dopamine-β-hydroxylase, DOPA decarboxylase, MAO-A, and MAO-B (IC50s = >1 µM for all); inhibits liver, duodenal, and brain S-COMT (ID50s = 5, 5, and 25 mg/kg, respectively); reduces 3-OMD formation and increases serum and brain L-DOPA, dopamine, and DOPAC levels when administered in combination with L-DOPA and carbidopa from 3-30 mg/kg; reduces mechanical and cold allodynia in a rat model of spinal nerve ligation-induced neuropathy at 30 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | OR-462 |
Gene, Accession, CAS # | CAS: 116313-94-1 |
Catalog # | 18656-5 |
Price | $73.00 |
Order / More Info | Nitecapone from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |