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Product Name | EPI-001 |
Description | An androgen receptor antagonist (IC50 = ~6 µM for inhibition of transactivation of the androgen receptor NTD); inhibits androgen-, FSK-, and IL-6-induced, as well as ligand-independent, PSA reporter gene expression in LNCaP cells expressing either the full length androgen receptor or a constitutively active mutant that lacks the ligand binding domain in a dose-dependent manner; inhibits androgen receptor interaction with the PSA androgen response element and blocks androgen-stimulated induction of endogenous PSA and 17 other androgen regulated genes in LNCaP cells; inhibits androgen-dependent and -independent growth of LNCaP and MDA-PCa-2B cells, but not 22Rv1, DU145, or PC3 cells that do not express the androgen receptor; reduces serum PSA and tumor growth in an LNCaP prostate cancer xenograft model in castrated mice when administered at a dose of 50 mg/kg, |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 882690-01-9 1297605-27-6 EPI001 ?H2O IL6 MDAPCa2B DU-145 PC-3 LT-313 |
Gene, Accession, CAS # | CAS: 227947-06-0 |
Catalog # | 16970-5 |
Price | $57.00 |
Order / More Info | EPI-001 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |