Doxepin (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | Doxepin (hydrochloride) |
| Description | A tricyclic antidepressant; binds to SERT and NET (Kds = 68 and 29.5 nM, respectively); a histamine H1 receptor antagonist (Ki = 1.23 nM); selectively binds to SERT and NET over DAT (Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively); binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-ARs (Kds = 27, 23, and 23.5 nM, respectively); decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain at 10 mg/kg, i.p.; increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress at 15 mg/kg |
| Size | 1 g |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 3607-18-9 25127-31-5 receptors antagonists inhibitors inhibits inhibitions neuroscie-nces signals transductions -inhibits inhibitions tricyclic antidepressants anti-depressants anti depressants reuptake re-uptake re uptake serotonin norepinephrine histamine adrenergic muscarinic HCl adapin aponal curatin doxepine P3693A P 3693A P-3693A quitaxon silenor sinequan sinequin P4599 P-4599 cis-Doxepin Sinequan |
| Gene, Accession, CAS # | CAS: 1229-29-4 |
| Catalog # | 15888-1 |
| Price | $37.00 |
| Order / More Info | Doxepin (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY