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Product Name | CAL-101 |
Description | A cell permeable inhibitor of the PI3K catalytic subunit p110δ (IC50 = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC50s = 820, 565, and 89 nM for p110α, β, and γ, respectively); blocks constitutive PI3K signaling in malignant B-cell lines and primary patient tumor cells, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and apoptosis |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Idelalisib|GS-1101 |
Gene, Accession, CAS # | CAS: 870281-82-6 |
Catalog # | 15279-10 |
Price | $63.00 |
Order / More Info | CAL-101 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |