RS 127445 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | RS 127445 (hydrochloride) |
| Description | A 5-HT2B receptor antagonist (Ki = 0.32 nM); selective for 5-HT2B over other 5-HT receptor subtypes (Ki = >3 µM for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3, 5-HT5, and 5-HT6); reduces contraction of rat isolated stomach fundus (pA2 = 9.5) and 5-HT-induced increases in intracellular calcium (IC50 = 0.04 nM); blocks (±)-α-methyl-5-HT-induced relaxation of isolated rat jugular veins (pA2 = 9.95); reduces peristaltic frequency and fecal output in mice in a dose-dependent manner; reduces basal, but not cocaine-induced, dopamine outflow in the nucleus accumbens of rats; decreases cocaine- or quinpirole-induced hyperlocomotion in rats |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 199864-87-4 RS127445 MT500 MT-500 5HT 5HT2B 5HT1A 5HT1B 5HT2C 5HT3 5HT5 5HT6 |
| Gene, Accession, CAS # | CAS: 199864-86-3 |
| Catalog # | 23451-5 |
| Price | $109.00 |
| Order / More Info | RS 127445 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY