FSL-1 (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY
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| Product Name | FSL-1 (trifluoroacetate salt) |
| Description | A synthetic lipopeptide agonist of TLR2/TLR6; increases NF-κB activity by 4- and 8-fold in HEK293 cells transfected with TLR2 and TLR6 but not TLR6 alone at 0.1 and 1 nM, respectively; induces the expression of the CCL20, IL-8, IL-1β, and TNF-α in THP-1 cells and, to a lesser extent, in TLR10 knockdown cells at 100 ng/ml; dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing CXCL10 when administered in combination with IFN-γ with a maximal increase of 50% at 0.5-50 µg/ml; induces fever and increases plasma levels of IL-6 and TNF-α by greater than 90-fold in rats at 100 µg/kg, i.p.; dose-dependently reduces locomotor activity and both food and water consumption with a maximal reduction of ten grams per 12 hours at 10-1,000 µg/kg, i.p. |
| Size | 500 µg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | FSL1 TLR-2 6 10 HEK-293 NFκB CCL-20 IL8 IL1β TNFα DM-13 VMM-1 CXCL-10 IL6 IFNγ THP1 322455-70-9 |
| Gene, Accession, CAS # | n/a |
| Catalog # | 24220-500 |
| Price | $97.00 |
| Order / More Info | FSL-1 (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY