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Product Name | IT1t (hydrochloride) |
Description | A CXCR4 antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively); selective for CXCR4 over hERG/Kv11.1 (IC50 = 13,240 nM); inhibits CXCL12-induced calcium mobilization in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM); inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated PHA-stimulated PBMCs; reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model at 20 µM |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 864677-55-4 1258011-83-4 IT 1t CXC CCR 4 CXCL 12 HIV1 NL43 43 MT4 MDAMB231B MDAMB 231B MDAMB231 |
Gene, Accession, CAS # | CAS: 1092776-63-0 |
Catalog # | 28434-5 |
Price | $110.00 |
Order / More Info | IT1t (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |