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Product Name | DL-TBOA |
Description | An EAAT inhibitor (IC50s = 67 and 5.5 µM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively); inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 µM) voltage-clamped at -60 mV; increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus at 500 µM; increases lesion volume in the rat hippocampal CA1 region when administereed intrahippocampally; induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges in rats at 25 nmol; induces antinociception in the second phase of the formalin test in rats at 5 and 10 µg when administered 10 minutes prior to formalin |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | DL-threo-β-Benzyloxyaspartate |
Gene, Accession, CAS # | CAS: 205309-81-5 |
Catalog # | 29632-5 |
Price | $184.00 |
Order / More Info | DL-TBOA from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |