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Antigenic Specificity | Human CD274 (B7-H1, PD-L1) |
Clone | W20262F |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2a, κ |
Format | purified, azide-free, low-endotoxin |
Size | 100 µg |
Concentration | n/a |
Applications | Block |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ultra-LEAF™ Purified anti-human CD274 (B7-H1, PD-L1). PD-L1, a member of the B7 family, is a type I transmembrane protein of 290 amino acids. Human PD-L1 has 70% amino acid identity to its mouse orthologue. Binding of PD-L1 to its receptor PD-1 leads to the inhibition of T cell receptor–mediated lymphocyte proliferation and cytokine secretion. PD-L1 induces IL-10 production in T cells stimulated with low levels of anti-CD3. PD-L1/PD-1 interaction suppresses immune responses against autoantigens and tumors and plays an important role in the maintenance of peripheral immune tolerance. Disruption of the PD-L1 gene leads to up-regulated T cell responses and the generation of self-reactive T cells. Antibodies against PD-1 or PD-L1 leads to increased antitumor immunity. PD-L1 has an important role in conferring fetomaternal tolerance in an allogeneic pregnancy model. Antibodies against PD-L1 lead to a breakdown in maternal tolerance to the fetus. PD-L1 shares its receptor with PD-L2 (CD273, B7-DC). PD-L2 has a more limited expression than PD-L1, being expressed on activated macrophages and dendritic cells. PD-L1 is expressed in many tumors, and the interaction with its receptor activates signaling pathways that inhibit T-cell activity and therefore the antitumor immune response. Antibodies targeting PD-1 or PD-L1 block the PD-1 pathway and reactivate T cell activity. |
Immunogen | Recombinant B7-H1 (PD-L1, CD274)-Fc |
Other Names | CD274, Programmed cell death 1 ligand 1 (PD-L1), B7 homolog 1 (B7h1) |
Gene, Accession # | Gene ID: 29126 |
Catalog # | 629553 |
Price | $415 |
Order / More Info | Human CD274 (B7-H1, PD-L1) Antibody from BIOLEGEND |
Product Specific References | n/a |