Description | Purified anti-p63 (ΔN). p63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. ΔN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, |
Product Specific References | PubMed: 18927616, 22336295, 25722207, 25849854, 25885474, 26538393, 28028137, 28028137, 28797033, 28923839, 29440247, 29588376, 29739933, 29588376, 28870520, 30135074, 29180475, 30267595, 28655168, 31113863, 31179162, 30478225, 31144617, 29357433, 31390564, 31390564, 31144617, 29588376, 29017029, 29217659, 31953387, 32081850, 29287803, 30737256, 32194398, 31523027, 31523027, 32915138, 31756437, 33414365 |