PDGFRA / Platelet Derived Growth Factor Receptor alpha Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-PDGFRA / Platelet Derived Growth Factor Receptor alpha antibody, protein, ELISA kits.
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| Antigenic Specificity | PDGFRA / Platelet Derived Growth Factor Receptor alpha |
| Clone | PDGFRA/7407 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-a and -beta, which are endowed with protein tyrosine kinase domains. PDGFR-a can bind to both A and B subunits of PDGF, while PDGFR-beta can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two a receptors, PDGF-AB induces dimerization of aa and abeta and PDGF-BB induces the formation of three types of dimers, aa, abeta and betabeta. Translocation of the PDGFR-beta gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. |
| Immunogen | A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the PDGFRA antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P16234 |
| Catalog # | orb1823457 |
| Price | $405 |
| Order / More Info | PDGFRA / Platelet Derived Growth Factor Receptor alpha Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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