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Antigenic Specificity | DBC2 / Deleted in breast cancer gene 2 / RHOBTB2 |
Clone | DBC2/4570 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2, kappa |
Format | unconjugated |
Size | 20 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis. |
Immunogen | A recombinant partial protein sequence (within amino acids 554-604) from the human protein was used as the immunogen for the Deleted in breast cancer 2 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: Q9BYZ6 |
Catalog # | orb1822893 |
Price | $405 |
Order / More Info | DBC2 / Deleted in breast cancer gene 2 / RHOBTB2 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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