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Antigenic Specificity | RAF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 100 ul |
Concentration | n/a |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to RAF1.RAF proto-oncogene serine/threonine-protein kinase AF1) belongs to the protein kinasesuperfamily. It acts as a regulatory link between the membrane-associated Ras GTPases and theMAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fatedecisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation.RAF1 can promote NF-kB activation and inhibit signal transducers involved in motility OCK2),apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis B1). It regulates Rhosignaling and migration, and is required for normal wound healing. Defects in RAF1 are the cause ofNoonan syndrome type 5 (NS5) and LEOPARD syndrome type 2 (LEOPARD2). |
Immunogen | N-terminal region of human RAF1 |
Other Names | RAF1,RAF protooncogene serine,threonineprotein kinase,cRaf,cRaf,RAF,CRAF,Raf1,ProtooncogenecRAF |
Gene, Accession # | UniProt: P04049 |
Catalog # | orb67278 |
Price | $527 |
Order / More Info | RAF1 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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