DTL Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | DTL |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 ul |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to DTL.Denticleless protein homolog (DTL) belongs to the WD repeat cdt2 family. It is a substrate-specificadapter for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cyclecontrol, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also namedCRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 andCDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure propercell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or followingUV irradiation is essential to control replication licensing. In undamaged proliferating cells, theDCX(DTL) complex promotes the 'Lys-164' monoubiquitination of PCNA to regulate PCNA-dependenttranslesion DNA synthesis. |
| Immunogen | N-terminal region of human DTL |
| Other Names | DTL,Denticleless protein homolog,CDT2,CDW1,DCAF2,L2DTL,RAMP,DDB1 and CUL4associatedfactor 2,Lethal(2) denticleless protein homolog,Retinoic acidregulated nuclear matrixassociatedprotein |
| Gene, Accession # | UniProt: Q9NZJ0 |
| Catalog # | orb67183 |
| Price | $527 |
| Order / More Info | DTL Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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