TRAIL R2 / DR5 Antibody from BIORBYT LTD.
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| Antigenic Specificity | TRAIL R2 / DR5 |
| Clone | DR5/3381 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes Fas antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the death domain, that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including Fas, DR2 (or TRUNDD), DR3 (death receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli. |
| Immunogen | A recombinant protein partial protein (amino acids 266-393) was used as the immunogen for this DR5 antibody. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | orb640015 |
| Price | $405 |
| Order / More Info | TRAIL R2 / DR5 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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