ZFYVE28 Antibody from BIORBYT LTD.
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| Antigenic Specificity | ZFYVE28 |
| Clone | LST2/2426 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. |
| Immunogen | A recombinant full-length human protein was used as the immunogen for this ZFYVE28 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q9HCC9 |
| Catalog # | orb639887 |
| Price | $764 |
| Order / More Info | ZFYVE28 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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