CD63 / LAMP-3 Antibody from BIORBYT LTD.
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| Antigenic Specificity | CD63 / LAMP-3 |
| Clone | rLAMP3/8604 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This mAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. |
| Immunogen | The smooth plasma membrane fraction of MeWo cells was used as the immunogen for the CD63 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P08962 |
| Catalog # | orb1825701 |
| Price | $405 |
| Order / More Info | CD63 / LAMP-3 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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