BRAF V600E Antibody from EAGLE BIOSCIENCES INC.

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Antigenic SpecificityBRAF V600E
Clonemonoclonal
Host SpeciesMouse
Reactive Speciesn/a
Isotypen/a
Formatunconjugated
Size0.1 ml
Concentrationn/a
ApplicationsRUO
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DescriptionSerine/Threonine-Protein Kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family, which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene, 80% of which are a single V600E substitution within the kinase domain, constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance. The V600E mutation is observed in colorectal cancer, non-Hodgkin's lymphoma, papillary thyroid carcinoma, malignant melanoma, non-small-cell lung carcinoma, and lung adenocarcinoma. BRAF V600E is therefore an important immunohistochemical marker for tumour diagnosis and prognosis.
Immunogenn/a
Other NamesIgG2b
Gene, Accession #n/a
Catalog #IHC600-100
Price$265
Order / More InfoBRAF V600E Antibody from EAGLE BIOSCIENCES INC.
Product Specific Referencesn/a
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
EAGLE BIOSCIENCES INC.
20A NW Blvd., Suite 112
Nashua NH 03063
P: 617-419-2019
P: 866-411-8023
F: 617-419-1110

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