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Antigenic Specificity | Ric-8A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, (presumed: rat, bovine, orangutan) |
Isotype | n/a |
Format | antigen affinity purified |
Size | 100 µl |
Concentration | 1000 µg/ml |
Applications | WB, IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-Ric-8A Antibody, Affinity Purified. RIC8 guanine nucleotide exchange factor A (Ric-8A), also known as Synmebryn-A, is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. It is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Ric-8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). It also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NPQ8]. |
Immunogen | Epitope: between 418 and 468 |
Other Names | Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog A; RIC8; synembryn-A |
Gene, Accession # | Gene ID: 60626, Accession: NP_068751.4, UniProt: Q9NPQ8 |
Catalog # | A304-572A |
Price | $433 |
Order / More Info | Ric-8A Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |