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Antigenic Specificity | TFEB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 10 µl |
Concentration | 1000 µg/ml |
Applications | WB, IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-TFEB Antibody, Affinity Purified. Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression; thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P19484]. |
Immunogen | Epitope: between 325 and 375 |
Other Names | ALPHATFEB; transcription factor EB; TCFEB; BHLHE35; class E basic helix-loop-helix protein 35; T-cell transcription factor EB |
Gene, Accession # | Gene ID: 7942, Accession: NP_009093.1, UniProt: P19484 |
Catalog # | A303-672A-T |
Price | $121 |
Order / More Info | TFEB Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |