TFEB Antibody from FORTIS LIFE SCIENCES

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Antigenic SpecificityTFEB
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatantigen affinity purified
Size10 µl
Concentration1000 µg/ml
ApplicationsWB, IP
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DescriptionRabbit anti-TFEB Antibody, Affinity Purified. Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression; thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P19484].
ImmunogenEpitope: between 325 and 375
Other NamesALPHATFEB; transcription factor EB; TCFEB; BHLHE35; class E basic helix-loop-helix protein 35; T-cell transcription factor EB
Gene, Accession #Gene ID: 7942, Accession: NP_009093.1, UniProt: P19484
Catalog #A303-672A-T
Price$121
Order / More InfoTFEB Antibody from FORTIS LIFE SCIENCES
Product Specific Referencesn/a
FORTIS LIFE SCIENCES
FORTIS LIFE SCIENCES
FORTIS LIFE SCIENCES
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