ERK1/2 pT202/pY204, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | ERK1/2 pT202/pY204, Human/Mouse |
| Clone | REA152 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ERK1/2 pT202/pY204 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA152 recognizes the phosphorylated threonine 202 and tyrosine 204 (pT202/pY204) of human ERK1 and pT184/pY186 of human ERK2, which are key components of the MAPK signaling cascade. ERK1 and ERK2 are multifunctional serine/threonine kinases and are ubiquitously expressed in mammalian cells. They share 85% homology and are phosphorylated by kinases MEK1/2 at Thr and Tyr residues within their activation loop leading to activation and nuclear translocation of ERKs. Activated ERKs phosphorylate downstream targets, such as signaling effectors, receptors, cytoskeletal proteins, and transcription factors. Owing to such a wide array of cellular targets, ERKs are involved in regulation of a number of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. Activation and mobilization of ERKs is induced in response to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein-coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neighbor to Proline residue. | Additional information: Clone REA152 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | MAPK1, MAPK3, ERK, ERK-2, ERK-1 |
| Gene, Accession # | Gene ID: 5595, 5594 |
| Catalog # | 130-103-621 |
| Price | $325 |
| Order / More Info | ERK1/2 pT202/pY204, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42 (4): 459-467. | Roskoski, R. et al. (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 66 (2): 105-143. | Lloyd, A. C. (2006) Distinct functions for ERKs? J. Biol. 5 (5): 13. | Gonzalez-Perez, G. et al. (2017) Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8+ T cell receptor signaling. Front Immunol 8: 265. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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