Edit |   |
---|---|
Antigenic Specificity | CD84, Mouse |
Clone | REA212 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 9 µg in 300 µL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD84 Antibody, anti-mouse, APC, REAfinity™. Clone REA212 recognizes murine CD84, a type I transmembrane glycoprotein belonging to the SLAM (CD150) family, a CD2 subset of the Ig superfamily of cell-surface receptors. Genes encoding for SLAM members are located on the syntenic region of mouse chromosome 1 and these receptors play vital role in regulation of innate and adaptive immune responses. CD84, like other SLAM receptors has an extracellular ectodomain formed by two Ig-like domains and a cytoplasmic domain with 2 copies of the ITSM (T-I/V-Y-x-x-V/I) motif, which is a docking site for SH2-binding phosphatases and the adaptor molecules SAP and EAT-2. CD84 serves as a self ligand and displays homophilic interaction via its N-terminal Ig domain. Expression of CD84 is found on a variety of cells including B, T, mast cell, platelets, monocytes, macrophages, granulocytes, dendritic cell and Hematopoietic stem cells (HSCs). CD84 has been implicated in regulation of functions such as T cell proliferation, FcεRI-mediated signalling in mast cells, and stability of platelets aggregates. | Additional information: Clone REA212 displays negligible binding to Fc receptors. | |
Immunogen | n/a |
Other Names | CDw84, SLAMF5, Ly9b, GR6 |
Gene, Accession # | Gene ID: 12523 |
Catalog # | 130-103-116 |
Price | $59 |
Order / More Info | CD84, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion: adhesion is mediated by Ig-like domain 1. J Immunol 167: 3668-3676. | Yan, Q. et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc. Natl. Acad. Sci. U.S.A. 104: 10583-10588. |