CD84, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD84, Mouse |
| Clone | REA212 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD84 Antibody, anti-mouse, PE, REAfinity™. Clone REA212 recognizes murine CD84, a type I transmembrane glycoprotein belonging to the SLAM (CD150) family, a CD2 subset of the Ig superfamily of cell-surface receptors. Genes encoding for SLAM members are located on the syntenic region of mouse chromosome 1 and these receptors play vital role in regulation of innate and adaptive immune responses. CD84, like other SLAM receptors has an extracellular ectodomain formed by two Ig-like domains and a cytoplasmic domain with 2 copies of the ITSM (T-I/V-Y-x-x-V/I) motif, which is a docking site for SH2-binding phosphatases and the adaptor molecules SAP and EAT-2. CD84 serves as a self ligand and displays homophilic interaction via its N-terminal Ig domain. Expression of CD84 is found on a variety of cells including B, T, mast cell, platelets, monocytes, macrophages, granulocytes, dendritic cell and Hematopoietic stem cells (HSCs). CD84 has been implicated in regulation of functions such as T cell proliferation, FcεRI-mediated signalling in mast cells, and stability of platelets aggregates. | Additional information: Clone REA212 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CDw84, SLAMF5, Ly9b, GR6 |
| Gene, Accession # | Gene ID: 12523 |
| Catalog # | 130-103-117 |
| Price | $47 |
| Order / More Info | CD84, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion: adhesion is mediated by Ig-like domain 1. J Immunol 167: 3668-3676. | Yan, Q. et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc. Natl. Acad. Sci. U.S.A. 104: 10583-10588. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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