Notch3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Notch3, Human |
| Clone | MHN3-21 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1κ |
| Format | biotin conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Notch3 Antibody, anti-human, Biotin. The MHN3-21 monoclonal antibody reacts with the extracellular domain of human Notch3, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multi-protein complex. Notch3 is expressed on various various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. It can also be expressed on vascular smooth muscle and cells of the central nervous system. In addition, the altered expression of Notch3 by various leukemias, lymphomas, and cancers has been reported. |
| Immunogen | n/a |
| Other Names | CADASIL, CASIL, IMF2, LMNS |
| Gene, Accession # | Gene ID: 4854 |
| Catalog # | 130-097-001 |
| Price | $264 |
| Order / More Info | Notch3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | n/a |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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