CD79a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD79a, Human |
| Clone | REA1168 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate, mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD79a Antibody, anti-human, PE, REAfinity™. Clone REA1168 regognizes the cytoplamic domain of CD79a, which is also known as MB-1 and Igα. Along with CD79b (Igβ), CD79a is associated with surface Ig (sIg) to form the B cell antigen receptor complex. CD79a is a 47 kDa glycoprotein and comprises a single extracellular immunoglobulin domain, a transmembrane domain, and a signaling intracellular domain with immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre-B cells from pro-B cells, surface expression of sIg, signal transduction following antigen recognition, and enodocytosis of recognised antigens. Surface expression of CD79a dimishes in plasma cells, where it is mainly found as an intracellular molecule. CD79 is considered a B cell-specific marker and is often used to identify the B cell lineage of acute lymphoblastic leukemia. Recent reports however suggest expression of CD79a in T cell acute lymphoblastic leukemia. Individuals lacking CD79a have low/absent circulating pre-B cells and serum antibodies due to a block in B cell development. | Additional information: Clone REA1168 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Igα, MB-1 |
| Gene, Accession # | Gene ID: 973 |
| Catalog # | 130-120-939 |
| Price | $119 |
| Order / More Info | CD79a, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Mason, D. Y. et al. (1991) The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells. J Immunol 147 (11): 2474-2482. | Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J Immunol 149: 1548-1555. | Koyama, M. et al. (1997) CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain. Int. Immunol. 9: 1767-1772. | Minegishi, Y. et al. (1999) Mutations in Igalpha (CD79a) result in a complete block in B-cell development. J. Clin. Invest. 104 (8): 1115-1121. | Lai, R. et al. (2000) Flow cytometric detection of CD79a expression in T-cell acute lymphoblastic leukemias. Am. J. Clin. Pathol. 113 (6): 823-830. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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