HLA-DR, DP, DQ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA-DR, DP, DQ, Human |
| Clone | REAL280 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-DR, DP, DQ Antibody, anti-human, PE, REAdye_lease™. Clone REAL280 is an antibody fragment derived from the full HLA-DR, DP, DQ antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL280 recognizes all major histocompatibility Class (MHC) class II HLA-DR, DP and most DQ antigens. It is expressed on several nucleated cells, e.g. B cells, interdigitating reticulum cells, Langerhans cells, activated T cells, and macrophages. MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4+ T cells, MHC class II molecules also mediate the thymic selection of helper T cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | MHC class II HLA-DR, MHC class II HLA-DP, MHC class II HLA-DQ |
| Gene, Accession # | n/a |
| Catalog # | 130-127-032 |
| Price | $430 |
| Order / More Info | HLA-DR, DP, DQ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nishimura, Y. et al. (1998) Peptide-based molecular analyses of HLA class II-associated susceptibility to autoimmune diseases. Int. Rev. Immunol. 17 (5-6): 229-262. | Jones, E. Y. et al. (2006) MHC class II proteins and disease: a structural perspective. Nat. Rev. Immunol. 6 (4): 271-282. | van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285 (52): 40800-40808. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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