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Antigenic Specificity | CX3CR1, Human |
Clone | 2A9-1 |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2bκ |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Immunohistochemistry, Western blotting, Immunocytochemistry, Intracellular flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CX3CR1 Antibody, anti-human, Biotin. CX3CR1 is a transmembrane chemokine receptor with a molecular mass of 40 kDa. It binds the chemokine CX3CL1, also known as fractalkine or neurotactin. Binding of CX3CR1 to the membrane?bound form of fractalkine promotes cell-cell adhesion, wheras the soluble form induces cell migration of CX3CR1-bearing cells such as monocytes, NK cells, T cells, dendritic cells (DCs), and macrophages including microglia. CX3CR1 plays also an important role in the formation of transepithelial dendrites by intestinal DCs. Failure in the fractalkine/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis. |
Immunogen | n/a |
Other Names | CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28 |
Gene, Accession # | Gene ID: 1524 |
Catalog # | 130-096-446 |
Price | $264 |
Order / More Info | CX3CR1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Niess, J. H. et al. (2005) CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307: 254-258. | Imai, T. et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530. |